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doi: 10.23937/2474-3658/1510121 62 Di MarcoF.FotiG.CorsicoA
Lead (Pb)-induced oxidative stress and toxicity reduced the expression of selenoprotein mRNAs, and the effect was mitigated by selenium supplementation 129
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Proteasomal degradation of p53 and its inhibition is constituted through E6 binding to the ubiquitin ligase enzyme, referred to as E6 associated protein (E6AP) [20, 21]
Causes: (a) Bland: Oral contraceptive pills, anabolic steroid, androgens (b) Inflammatory: Allopurinol, co-amoxiclav, carbamazepine (c) Ductal: Chlorpromazine, flucloxacillin Steatosis: Hepatotoxicity may manifest as triglyceride accumulation which leads to either small droplet (microvesicular) or large droplet (macrovesicular) fatty liver
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